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Studies have shown that spironolactone reduces sebum excretion in the skin by about 30-50 percent and therefore is very effective in those with oily skin. Being an oral medication, it has the possibility to cause more side effects than topical treatments. The most common side effects are excess urination, menstrual irregularities (spotting etc.) and low blood pressure. The menstrual irregularities are usually decreased in woman who are also taking oral hormonal contraceptives. Many compounding pharmacies make topical spironolactone which can sometimes help reduce side effects. It is not commercially available though at retail pharmacies. Antibiotics (Topical) When To Use/Place In Therapy As part of combination therapy for mild to severe acne. Topical antibiotics should never be the sole treatment for several reasons including the extended time it takes to see positive effects and the fact that bacterial resistance can occur. It's important to note that acne is not an infection. Everyone carries a bacteria in their skin known as P. acnes. The problem is when the bacteria over grows in the skin. Some byproducts of the metabolism of the P. Acnes bacteria are irritants to the skin and lead to microcomedo formations and results in inflammatory lesions. Decreasing the amount of Prances via antibiotic therapy is usually associated with acne improvement.

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